Poor/In depth Metabolizers, CYP2D6 The development from the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around seven% of the population has decreased action of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme program. These individuals are “inadequate metabolizers” of debrisoquine, dextromethorphan and tricyclic antidepressants, amid other drugs. https://luisa208elq4.yourkwikimage.com/user